Research on New Treatments for Neglected Tropical Diseases (NTDs)

The joint venture provides DNDi access to selected classes of AbbVie's proprietary molecules to guide the search for improved treatments for NTDs, including Chagas disease, helminth infections, leishmaniasis and sleeping sickness.

Boosting Innovation for NTDs

Since 2009, AbbVie has provided compounds for DNDi to screen for activity against neglected diseases. Currently, AbbVie is working with DNDi to follow up on screening hits for parasites causing visceral leishmaniasis and Chagas’ disease, and nematodes causing river blindness and lymphatic filariasis. Promising compounds are entered into the AbbVie-DNDi collaboration agreement the provides DNDi a non-exclusive license to relevant AbbVie IP for use in the neglected diseases field. Any resulting products will be provided in endemic countries at the lowest sustainable price to expand patient access. AbbVie scientists also provide technical expertise to DNDi and participate as team members in DNDi discovery groups.

AbbVie also has a partnership with the Liverpool School of Tropical Medicine (LSTM) to help discover new macrofilaricides acting through an anti-Wolbachia mechanism. AbbVie is conducting the chemistry, DMPK, formulation and safety studies, and LSTM is conducting the in vitro anti-Wolbachia and animal efficacy screening.

Partners

  • AbbVie

    Service Providers
    United States | Staff size: 10,000+

    AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise...

  • Drugs for Neglected Diseases Initiative (DNDi)

    Association
    United States | Staff size: 251-500

    Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients’ needs-driven, non-profit drug research and development (R&D) organization that is...

  • Liverpool School of Tropical Medicine (LSTM)

    Institute
    United Kingdom | Staff size: Unknown

    The Liverpool School of Tropical Medicine (LSTM) is an international centre of excellence, devoted to research, postgraduate education and training, and consultancy. A registered charity...

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Key Information

LocationLatin America and Caribbean, West Africa, Southern Africa, South Asia, North Africa and Middle East, Eastern Africa, Central Asia, Central Africa
StatusActive
  • Start Date 2009
Sectors