Typhoid/Paratyphoid Vaccine Development in India

A collaboration to deliver affordable vaccines for typhoid and paratyphoid A fevers to low-and-middle income coutries.

Collaboration in India for Typhoid/Paratyphoid Vaccine Development

Novartis has entered into a development and licensing agreement with Biological E Limited (BioE), a biopharmaceutical company based in India, for two vaccines to protect against typhoid and paratyphoid fevers. The agreement advances the Novartis goal to deliver accessible and affordable vaccines that address unmet medical need in endemic regions.

Under the license, NVGH will transfer technology to BioE, which will have financial and operational responsibility for manufacturing, further clinical development, approval and distribution in the developing world. The typhoid vaccine (Vi-CRM197) has achieved Proof of Concept, had successful Phase 2 results, and will be transferred to BioE. A combined typhoid-paratyphoid vaccine will be transferred once Proof of Concept is completed through early, small-scale studies in humans to determine safety and immunogenicity.

In addition, a dual-acting vaccine with components against both typhoid and paratyphoid fevers is being developed with on-going support from the Wellcome Trust. Both could reduce the burden of these diseases in endemic regions.

The typhoid vaccine (Vi-CRM197) has achieved successful clinical proof-of-concept and Phase 2 clinical trials and is now in the process of being transferred to BioE. A combined typhoid-paratyphoid vaccine that is still undergoing testing at NVGH will be transferred to BioE once clinical proof-of-concept will be completed through early, small-scale human studies to determine safety and immunogenicity.


  • Novartis AG

    Goods Supplier
    Switzerland | Staff size: 10,000+

    Novartis AG, was incorporated on 1996, provides healthcare solutions. The Company is a multinational group of companies specializing in the research, development, manufacturing and marketing of...

  • Biological E. (Bio E)

    Goods Supplier
    India | Staff size: 1001-5000

    Biological E., Ltd. (Bio E) is a globally focused biopharmaceutical company that develops, manufactures and markets innovative vaccines, branded generics and novel therapeutics that respond to...

  • Wellcome Trust

    Funding Agencies, Foundation
    United Kingdom | Staff size: 501-1000

    Wellcome Trust is a global charitable foundation, both politically and financially independent. The foundation supports scientists and researchers, take on big problems, fuel imaginations, and...

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Key Information

LocationSouth Asia, India
  • Start Date 2013