GSK Biologicals and the Oswaldo Cruz Foundation (FioCruz) initiated their first collaboration with an agreement to supply oral polio vaccines in 1985. Since then, GSK Biologicals and Fiocruz have formed several strategic alliances to provide Brazilians with key vaccines, including vaccines against Haemophilus influenzae type b (Hib), MMR (measles, mumps and rubella) and rotavirus. This is the partners’ first collaboration on an R&D center that will focus on the development of new vaccines.
The extended vaccine partnership between GSK and FioCruz aims to create a joint R&D initiative to develop a vaccine for dengue fever. Scientists from GlaxoSmithKline in Belgium, where GSK’s vaccines division is headquartered, and FioCruz in Brazil, will be involved in the new partnership which should help to enhance Brazilian vaccine R&D capacity.
The partnership establishes a research and development program that will be conducted jointly by GSK and Fiocruz to develop a vaccine for the prevention of dengue fever; the sharing of specific knowledge and development expertise between the partners is thought to be key to accelerate the development of the vaccine candidate towards its registration in Brazil at first.
The challenges of the dengue vaccine approach (use of four serotypes and potential interferences, role of the neutralizing antibodies to avoid promoting more severe form of the disease) are addressed by the common development program which is reviewed and updated regularly by the joint management committee which is governing the collaboration between the GSK and Fiocruz partners.
Attached to the Brazilian Ministry of Health, Fiocruz is the most prominent science and technology health institution in Latin America given the mission of fighting the great problems of public health in Brazil. Alongside research development the institution works in production of vaccines, drugs, diagnostic kits, education and training of human resources, quality control of products and services and the implementation of social programs.
|Location||Latin America and Caribbean, Brazil|