Partnership to Advance Drug Formulation to Help Prevent HIV Infection

PATH has entered into a new licensing agreement with pharmaceutical company Janssen R&D Ireland to develop an injectable form of the medicine rilpivirine that could provide a new tool in the fight to stop the spread of HIV.

Developing a PrEP for HIV Prevention

Janssen Pharmaceutical Companies of Johnson & Johnson and its partner Program for Appropriate Technology in Health (PATH) are exploring innovative applications of HIV medicines to improve treatment outcomes in hard-to-reach areas by finding ways to reduce the frequency of dosing.

In September 2013, Janssen R&D Ireland signed a license agreement with PATH for the early development of the human immunodeficiency virus type 1 (HIV-1) medicine rilpivirine in a long-acting injection (depot formulation) as potential PrEP against HIV infection.

Under the terms of the agreement, a Drug Development program of PATH, an international nonprofit organization that transforms global health through innovation, has the right to develop rilpivirine long-acting formulation as a possible new way to prevent HIV infection. PATH has the intent to conduct prophylaxis clinical trials in collaboration with partners including the HIV Prevention Trials Network. Following the completion of the clinical Phase 2 program, PATH and Janssen will evaluate entering into a late stage development agreement covering the use of rilpivirine as PrEP for uninfected individuals at high risk of acquiring HIV.


  • Janssen

    United States | Staff size: 10,000+

    Janssen Research & Development, LLC, is united and energized by one mission – to discover and develop innovative medicines that ease patients' suffering, and solve the most important...

  • PATH

    Implementing NGO
    United States | Staff size: 501-1000

    They dare to believe that innovation can change the world

    PATH is the leader in global health innovation. An international nonprofit organization, they save lives and improve health,...

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Key Information

LocationCentral Africa, Eastern Africa, Zimbabwe, Zambia, Uganda, Togo, Tanzania, Swaziland, Sudan, Southern Sudan, South Africa, Sierra Leone, Seychelles, Senegal, Sao Tome and Principe, Rwanda, Nigeria, Niger, Namibia, Mozambique, Mauritius, Mauritania, Mali, Malawi, Madagascar, Liberia, Lesotho, Kenya, Guinea-Bissau, Guinea, Ghana, Gambia, Gabon, Ethiopia, Eritrea, Equatorial Guinea, Cote d Ivoire, Congo, The Republic of, Congo, The Democratic Republic of, Comoros, Chad, Central African Republic, Cape Verde, Cameroon, Burundi, Burkina Faso, Botswana, Benin, Angola, West Africa, Southern Africa
  • Start Date 2013