Janssen R&D Collaboration with TB Alliance

Janssen Pharmaceuticals, in collaboration with the TB Drug Development (TB Alliance), will share expertise and resources in the development of Bedaquiline (TMC207), as part of the new regimen for drug-sensitive TB. The product development partnerships will accelerate the discovery and development of new TB drugs that will shorten treatment of the disease.

Janssen R&D Collaboration with TB Alliance

Janssen Pharmaceutical Companies of Johnson & Johnson and the non-profit Global Alliance for TB Drug Development (TB Alliance) share their expertise and resources in the development of TMC207, which could become the first TB drug with a new mechanism of action in 40 years. Under the terms of the agreement, Janssen is developing TMC207 for the treatment of MDR-TB and, on approval, will work with global (Stop TB Partnership, WHO, etc.), regional and local stakeholders to ensure the product is appropriately used in accordance with international standards, affordable and available to patients in need. The agreement grants the TB Alliance a royalty-free license for the worldwide development and access to TMC207 in the field of drug-susceptible TB. Janssen and the TB Alliance will share expertise and resources in the development of TMC207. A number of Early Bactericidal Activity (EBA) studies have been conducted to establish dose finding and to facilitate new regimen selection. Drug-Drug Interaction (DDI) studies are also underway. In addition, Janssen collaborates with the TB Alliance in a discovery research program to identify other new compounds for the treatment of TB. The rights for the newly discovered compounds for the treatment of tuberculosis will belong to the TB Alliance under a royalty-free license.

Partners

  • Janssen

    Institute
    United States | Staff size: 10,000+

    Janssen Research & Development, LLC, is united and energized by one mission – to discover and develop innovative medicines that ease patients' suffering, and solve the most important...

  • World Health Organization (WHO)

    Funding Agencies
    Staff size: 5001-10,000

    WHO (World Health Organisation) is the directing and coordinating authority for health within the United Nations system. It is responsible for providing leadership on global health matters,...

  • Stop TB Partnership

    Implementing NGO, Institute
    United States | Staff size: Unknown

    The Stop TB Partnership is leading the way to a world without tuberculosis (TB), a disease that is curable but still kills three people every minute. Founded in 2001, the Partnership's mission...

  • Global Alliance for TB Drug Development (TB Alliance)

    Advocacy NGO
    United States | Staff size: 26-50

    The Global Alliance for TB Drug Development (TB Alliance) is a not-for-profit, product development partnership accelerating the discovery and development of new tuberculosis (TB) drugs that will...

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Key Information

LocationWorldwide
StatusActive
  • Start Date 2003
Sectors