PATH is an international nonprofit organization working to improve global health. The PATH Malaria Vaccine Initiative (MVI) is a highly focused vaccine development program launched in 1999 with a $50 million grant from the Bill & Melinda Gates Foundation. MVI seeks to accelerate the development of promising malaria vaccines and ensure their availability and accessibility in the developing world. When MVI was created, several academic and governmental organizations and pharmaceutical companies had already been working on approaches to developing malaria vaccines with the potential to have an impact on malaria. MVI catalyzed the acceleration of those efforts by providing funds as well as logistical and technical support to advance promising projects into clinical development. MVI currently maintains a diverse portfolio of preclinical, early clinical and one advanced clinical project. The Bill & Melinda Gates Foundation, USAID and the ExxonMobil Foundation have been the primary funding partners for the initiative. To date, the Bill & Melinda Gates Foundation has committed a total of $456 million in grants to MVI.