The Accelerating Market-Driven Partnerships (AMP) initiative is a public-private partnership that seeks to mobilize innovation and investment around critical global challenges such as poverty, climate change, sustainable cities and waste, and addressing agricultural value chain waste in key growth markets. While AMP is a global initiative, the pilot initiative will initially focus on promoting sustainable cities and waste management issues in Brazil. AMP will draw on the resources of partners in both Brazil and the United States to bring a business eye to taking on social and environmental problems in developing markets. The pilot initiative in Brazil will build on the Department of Housing and Urban Development’s work on the Energy and Climate Partnership of the Americas to advance sustainable and inclusive cities and housing. In collaboration with the U.S. Department of State, AMP will also develop an “Innovation Toolkit” that identifies critical elements necessary to strengthen science and technology, and to foster the development of entrepreneurship and innovation ecosystems. AMP will provide a platform for businesses, private investors, social entrepreneurs, government, multilateral institutions and philanthropic organizations to identify and tackle key environmental, social and economic challenges in countries that are transitioning from development assistance.