The Maryland Patient Safety Center was established by the Maryland Legislature in 2003 and first received designation by the Maryland Health Care Commission in 2004. The Maryland Hospital Association and the Delmarva Foundation were jointly selected as operators of the Center for a three-year period, starting in January 2004. State designation was extended for two additional one-year periods through December 2008.
In September 2007, the Center became an incorporated organization. As a not-for-profit organization, a voluntary board of directors sets the strategy for the organization.
The Maryland Patient Safety Center was redesignated as the state's patient safety organization for an additional five years, beginning January 1, 2009 through December 31, 2014. In addition, it was one of the first 25 organizations in the nation to be listed as a Patient Safety Organization (PSO) by the federal Agency for Healthcare Research and Quality (AHRQ) under provisions of the Patient Safety and Quality Improvement Act of 2005. In November 2014, the Center named Mid-Atlantic Patient Safety Organization
as a component PSO of the Center. The state redesignated the Mid-Atlantic Patient Safety Organization as the state's patient safety organization for another five years, beginning January 1, 2015 through December 31, 2019.