With U.S. government cuts upending the INGO funding model, many of the largest U.S.-based international nonprofits are facing unprecedented financial pressure. These organizations, which deliver critical services across health, education, humanitarian aid, and more, are navigating a rapidly shifting landscape — and the stakes couldn’t be higher.

This exclusive report ranks the 50 largest U.S. international NGOs in 2025 and analyzes how they’re weathering one of the most significant disruptions in recent memory. Backed by fresh data from the U.S. Internal Revenue Service’s Form 990 and Devex’s in-depth funding analysis, it offers a clear, data-driven look at who’s rising, who’s at risk, and what the future may hold for one of global development’s most important sectors.

What you'll learn:

• The 50 largest U.S.-based INGOs ranked by latest available revenue.
• How U.S. government funding cuts — including USAID cancellations — are reshaping the sector.
• Which organizations are most exposed to government grants, and how that’s affecting their stability.
• The breakdown of revenue sources across public donations, foundations, and government grants.
• Compensation trends among top executives at the largest INGOs.

Whether you're a donor, policymaker, or development professional, this is essential reading for understanding the health, resilience, and future of U.S. international NGOs in 2025.