The Institute was established on 3 January 1962 comprising two units: Silk cum Lac Research Institute and Silk Technological Institute under the then East Pakistan Small & Cottage Industries Corporation (EPSCIC). In 1974 two units were combined together and named as Silk Research and Training Institute.

n 1978 Bangladesh Sericulture Board (BSB) was created and the Institute was brought under the control of BSB and renamed as Bangladesh Sericulture Research & Training Institute (BSRTI) in 1980.

The Government separated Bangladesh Sericulture Research and Training Institute (BSRTI) from BSB and established as an Independent Institute through the Act no. 25 of 2003.

 In 2013 Bangladesh Sericulture Development Board (BSDB) is formed through unification of Bangladesh sericulture Board, Bangladesh Sericulture Research and Training Institute and Bangladesh Silk foundation. The Institute is included as a member of National Agriculture Research System (NARS) in 2012 by the act of BARC- 2012.