Botswana-Baylor Children’s Clinical Centre of Excellence (Botswana-Baylor) is a national HIV/AIDS care and treatment facility that provides services in Gaborone, Botswana, for HIV-infected children, adolescents, and young adults and their families from around the country. It is a public-private partnership between the government of Botswana and the Baylor College of Medicine - Baylor International Pediatric AIDS Initiative (BIPAI), which was launched in June 2003. Botswana-Baylor is registered under the laws of Botswana as a Trust. It is located on the campus of the Princess Marina Hospital, a tertiary care referral hospital.

Botswana-Baylor provides free-of-charge, state-of-the-art pediatric HIV care, treatment, and support to children, adolescents, and their families at the main clinic in Gaborone and through decentralized outreach services across the country. Botswana-Baylor is a leader in the field of pediatric HIV care in Botswana, the Southern Africa region and beyond.