The Children’s Tumor Foundation is revolutionizing the field of NF research and we’re proud of the recent achievements.

From 2010 to 2015, the Children’s Tumor Foundation’s primary objective has been to fill the clinical drug development pipeline. CTF strategically integrated investments into this clinical pipeline, resulting substantial accomplishments by the end of those five years:

• Over 70% of all NF data in the world has been funded or co-funded by CTF. 
• CTF investments in the last five years ($26.6M) have already attracted $38.4M in follow-up funding from other sources.
• CTF’s NF Preclinical Consortium and NF Therapeutic Consortium (NFPC and NFTC) have generated 95 preclinical studies which have led to 16 clinical trials.
• One of those trials (MEK inhibitor) resulted in over 50% of participants in a clinical trial seeing a reduction of at least 20% in their inoperable plexiform neurofibromas.
• CTF created the NF Registry, which attracted over 6,600 patients by the end of 2015, and whose information was utilized 22 times to recruit patients to clinical trials.
• The CTF Biobank collected more than 200 tissue samples.
• CTF funding led to more than 62 publications.
• CTF built an innovative research model called Synodos, which attracted a “dream team” of scientists who pledged to work together collaboratively.
• CTF launched an NF data hub, providing an open access data platform to all.

The accomplishments of the past enable CTF to turn their eyes toward lofty goals. The strategy for the next five years is to double the speed of clinical therapies to the clinic. CTF is advancing to Synodos consortia, increasing our NF data hub, growing the CTF Biobank, and expanding the NF Registry. With your help, the hope for the future includes partnerships with the pharmaceutical industry and the creation of an NF Biomarker Center to discover measureable biological indicators for NF.

CTF is planning for a future in which there are approved drugs for the treatment of NF. Thanks to you, we are advancing this vision!