The Ministry of Science, Technology and Innovation, abbreviated MOSTI, is a ministry of the Government of Malaysia.

In the Seventh Mahathir cabinet, the entire component of the Ministry of Science, Technology and Innovation (MOSTI), Green Technology and Energy Components from the Ministry of Energy, Green Technology and Water (KeTTHA) and related components of Climate Change and Environment from the Ministry of Natural resources and Environment (NRE) has been restructured and formed the Ministry of Energy, Science, Technology, Environment & Climate Change (MESTECC). After the 2020 Malaysian political crisis, MESTECC has been restructured and its name has been changed to the Ministry of Science, Technology and Innovation (MOSTI) following the formation of the Muhyiddin cabinet.