The U.S. Mission has been in Guinea since the country’s independence in 1958. The Embassy was first located in downtown Conakry in Kaloum until 2006, when it moved to a new building in Koloma.

The U.S. Mission to Guinea comprises 5 agencies of the United States Government: the Department of State, the U.S. Agency for International Development (USAID), the Department of Defense, the U.S. Centers for Disease Control and Prevention (CDC), and the U.S. National Institutes of Health (NIH). Peace Corps volunteers work throughout the country on projects related to education, public health, agro-forestry and community economic development.  Ambassador Dennis Hankins has been the Chief of Mission since November, 2015.