The Nuffield Department of Women's & Reproductive Health encompasses multi-disciplinary research across the full spectrum of women’s health. Their work has four overarching themes; Cancer, Global Health, Maternal & Fetal Health and Reproductive Medicine & Genetics. 

Their clinical and laboratory-based research programmes are based in the Women’s Centre, the Weatherall Institute of Molecular Medicine (both at the John Radcliffe Hospital) and the Institute of Reproductive Sciences (IRS), Oxford Business Park. They have extensive collaborations with a number of University Science Departments and other research groups in the UK and abroad. The department's main offices are on level 3 of the Women’s Centre (John Radcliffe Hospital, Oxford) which is responsible for the care of over 7,000 pregnant women and over 7,500 new gynaecology patients per year. The hospital is a tertiary referral centre for obstetric medicine, pre-natal diagnosis, endometriosis, reproductive medicine, IVF, urogynaecology and gynaecological oncology. 

In addition to undertaking worldwide acclaimed research, they also teach students and provide clinical care for Oxford University Hospitals NHS Trust. In 2008 they established the MSc Course in Clinical Embryology, a world-class course that has won numerous University awards for teaching innovation and excellence. They supervise research students (MSc by research and D.Phil) and teach clinical undergraduate students as part of their medical degree.