The United States established diplomatic relations with Switzerland in 1853 following the formation of a unified Swiss state. Switzerland is a democratic country subscribing to the fundamental ideals with which the United States also is identified. The country is politically stable with an essentially strong economy. It has played an increasingly important role in supporting the spread of democratic institutions and values worldwide, as well as providing humanitarian relief and economic development assistance. U.S. policy toward Switzerland takes these factors into account and seeks to cooperate with Switzerland to the extent consistent with Swiss neutrality.

The United States and Switzerland have signed a number of agreements creating mechanisms that deepen cooperation and improve the relationship: the Enhanced Political Cooperation Framework, the Trade and Investment Cooperation Forum, and the revised Operative Working Arrangement on Law Enforcement Cooperation on Counterterrorism. The centerpiece of the Enhanced Political Cooperation Framework is an annual senior-level meeting, the Joint Working Group. Another vehicle for bilateral cooperation is the U.S.-Swiss Joint Economic Commission, which covers anti-money laundering efforts, counterterrorism, regulatory cooperation, and intellectual property rights, among other topics.