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    Supply of one of the world's oldest antibiotics under threat

    Benzathine penicillin G is a cheap and critical treatment for syphilis and rheumatic heart disease. But supply of the antibiotic, particularly in lower-income countries, is threatened by persistent production challenges.

    By Andrew Green // 20 July 2023

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    The fragile supply of one of the world’s oldest antibiotics, benzathine penicillin G, which is critical for treating syphilis and preventing and managing rheumatic heart disease, is at risk.

    Pfizer has announced a shortage of its version of the injectable, long-acting form of penicillin, which the company markets as Bicillin. The pharmaceutical company said it could take up to a year for its supply to recover.

    But if Pfizer, which sells primarily to high-income countries, begins to stockpile the active pharmaceutical ingredient, or API, needed to produce the final product, it could trigger a chain reaction that would lead to even longer-term shortages in lower-income countries.

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    Read more:

    ► The climate emergency is turning fragile supply chains into a crisis

    ► Cheaper HIV/syphilis combo tests aim to reduce newborn deaths

    ► Are we on the verge of closing global gaps in diagnostics?

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    About the author

    • Andrew Green

      Andrew Green@_andrew_green

      Andrew Green, a 2025 Alicia Patterson Fellow, works as a contributing reporter for Devex from Berlin.

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